TB-500 (Thymosin Beta-4 fragment) · 5 June 2026
TB-500: Thymosin Beta-4 and the Cell-Migration Literature
Essential Peptides Au · Journal · 3 min read
A synthetic fragment of the naturally occurring Thymosin Beta-4 protein, which is involved in actin sequestration and cellular migration. Investigated in repair and regeneration models, often alongside BPC-157 in comparative studies. Most of the published work focuses on its role in the early stages of tissue response rather than long-term outcomes.
Mechanism in brief
TB-500 corresponds to the active fragment of thymosin β4 containing the actin-sequestering LKKTET motif. It binds G-actin with high affinity, reduces the G/F-actin ratio, and modulates cell-migration and angiogenesis signalling in scratch-assay models.
In current research
G-actin sequestration and F/G-actin ratio assays are common, typically run alongside cell-migration and scratch-wound readouts. Because its lyophilised appearance is similar to other short fragments, clear labelling and supplier-confirmed sequence identity matter when several peptides are open at once.
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TB-500 (Thymosin Beta-4 fragment) in the catalogue
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For research use only. This article is provided for research and educational purposes and does not describe or imply therapeutic use. None of these compounds are for human or veterinary consumption.